Males had a median income of ,742 versus ,453 for females. About 5.5% of families and 6.2% of the population were below the poverty line, including 9.1% of those under age 18 and 5.7% of those age 65 or over.South San Francisco is a middle class and working class city.January is the coolest month with August being the warmest month.
In 1853 Charles Lux and a business partner, Alfred Edmondson, purchased 1,700 acres (7 km The city of South San Francisco was originally conceived as an industrial suburb and was promoted by representatives of the Beef Trust, a group including some of the country's largest meat packing firms.
There were 20,118 households out of which 39.2% had children under the age of 18 living with them, 51.8% were married couples living together, 11.2% had a female householder with no husband present, and 28.5% were non-families.
21.9% of all households were made up of individuals and 8.0% had someone living alone who was 65 years of age or older.
The major manufacturers closed, and new development was focused on office parks, housing, high-rise hotels, and yacht harbors.
The biotechnology giant Genentech opened in 1976, leading to South San Francisco's new identity as "the birthplace of biotechnology".) of it (69.69%) is water.
It has tripled since World War II with the opening of such subdivisions as Buri Buri, Winston Manor and Westborough on the slopes west of El Camino; The city is particularly noted for the South San Francisco hillside sign on Sign Hill, which rises to the north of the city, with large white letters that proclaim "South San Francisco, The Industrial City".